Imaging is one of the key data acquisition technologies in medicine and life sciences and an extremely fast evolving technology delivering increasingly detailed insights into structure and function of organisms. This rich source of information enables fundamental insights into biological processes, but also supports the ongoing efforts to realize personalized medicine. However, scientists and physicians are confronted with an ongoing explosion of imaging data that has to be processed, inspected, analyzed and correlated and the ability to efficiently get access to the core information encoded in this data decides on its final usefulness.