CONFOCAL BRILLOUIN LIGHT SCATTERING MICROSCOPY & SPECTROSCOPY
The researchers in our team specialize in developing novel optical microscopy and spectroscopy techniques to elucidate the microscopic-scale mechanical, structural, and dynamic properties of biological matter. These techniques provide insight into the anatomical relevance, functional relevance, and medical relevance of biological structures, such as their role in development, locomotion, and signaling/information transduction, as well as their relation to pathologies and potential for prognostics and diagnostics.
Our techniques enable all-optical, label-free measurements of the hypersonic velocity and attenuation in a material, allowing for calculations of elastic and viscous moduli relevant for picosecond-scale perturbations and identification of structural symmetries. Spatial resolution of measurements can be as fine as ~0.5 μm for elastic and ~2 μm for viscous properties, with a typical temporal resolution (time for acquisition of a spectrum) ranging from 20ms to 10s depending on laser power, setup, and sample
Application
– ‘Brillouin Scattering Atlas of the Human Body’
– Bioavailability assays
– Viscoelastic and rheological properties of biofluids
– Mechanical signaling and information transduction processes
– Novel optical microspectroscopy approaches
– Connection between microscopic scale viscoelastic anisotropy and microscopic anatomy
– Multimodal
– Spatial and temporal mapping
