A research infrastructure project has been approved by the Austrian #BMBWF. In this project 3 cutting-edge #imaging technologies (live cell nanoscopy, cellular-resolved genomic analysis, and BioBrillouin vibrational microscopy) will be set up at the Core Facilities of the Vetmeduni and Medizinische Universität Wien. This funding will expand the imaging portfolio......
The Austrian BioImaging Steering Committee held its annual meeting in December 2023. Baubak Bajoghli, the new Director of Austrian BioImaging, reported on the activities and achievements in 2023. He also presented a clear strategic vision for the future to achieve greater visibility and recognition, create opportunities for innovation and scientific......
Using the single-molecule fluorescence microscopy modality “TOCCSL” and flux assays, the subunit stoichiometry and function of the norepinephrine transporter (NET) was investigated. NET was found to form monomers (~60%) and dimers (~40%) at the plasma membrane. The average oligomeric state was found to decrease upon PIP2 depletion. Authors: Dino Luethi 1 2, Julian Maier 1, Deborah......
Careful phenotype analysis of genetically altered mouse embryos/fetuses is vital for deciphering the function of pre- and perinatally lethal genes. Usually this involves comparing the anatomy of mutants with that of wild types of identical developmental stages. Detailed three dimensional information on regular cranial nerve (CN) anatomy of prenatal mice......
Short description: Comulis has opened an activity that is centered on “mobility grants”, also called Short-Term Scientific Missions (STSMs). In a Nutshell, Early Career Investigatos (ECI) and and Experience Image Scientists, from Research Labs, Core facilities or Industry, can apply for funds to cover their expenses when visiting a Host......
This PhD project focuses on the combination of imaging approaches which allow to bridge the gap between different resolutions, from the nano to the macro scale, and approaches looking for already known analytes (targeted analysis) or visualizes structures by highlighting the distributions of yet unknowns (untargeted). With a strong emphasis......
Approximately one-third of randomly produced knockout mouse lines produce homozygous offspring, which fail to survive the perinatal period. The majority of these die around or after embryonic day (E)14.5, presumably from cardiovascular insufficiency. For diagnosing structural abnormalities underlying death and diseases and for researching gene function, the phenotype of these......